The purpose of this research work was to develop and evaluate matrix-type transdermal therapeutic system containing Nicardipine hydrochloride with different ratios of hydrophilic and hydrophobic polymeric combinations by the solvent evaporation technique. The physicochemical compatibility of the drug and the polymers was studied by infrared spectroscopy. The results suggested no physicochemical incompatibility between the drug and the polymers. Seven transdermal patch formulations (F-1, F-2, F-3, F-4, F-5, F-6, F-7) consists of Hydroxypropyl methylcellulose E5 and Ethyl cellulose in the ratios of 8:0, 0:8, 2:6, 3:5, 5:3, 6:2, 4:4 respectively were prepared. All formulations carried dimethyl sulfoxide as penetration enhancer and dibutyl phthalate as plasticizer in acetone and methanol (4:3) as solvent system. The prepared transdermal patches were evaluated for in vitro release, moisture absorption, moisture loss and mechanical properties. The diffusion studies were performed by using modified Franz diffusion cells. The formulation, F-1 (Hydroxypropyl methylcellulose E5 alone) showed maximum release of 97.1887 ± 0.566 % in 7 hrs, where as F-2 (Ethyl cellulose alone) showed maximum release of 66.9393 ± 1.812 % in 24 hrs. The formulation, F-7 with combination of polymers (4:4) showed maximum release of 91.7772 ± 0.780 % in 24 hrs, emerging to be ideal formulations for Nicardipine hydrochloride. The developed transdermal patches increase the efficacy of Nicardipine hydrochloride for the therapy of hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina.
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